Factors involved in the rate of fall of thyroid stimulating hormone in treated hypothyroidism
London
Centre for Paediatric Endocrinology, Great Ormond Street
Hospital for Children, London WC1N 3JH
Correspondence to: Professor Brook.
Accepted 7 July 1997
The rate of fall of serum thyroid stimulating hormone (TSH)
concentrations in 32 hypothyroid infants (11 boys, 21 girls) was studied after starting treatment with thyroxine to determine whether it
was influenced by initial TSH concentration or the cause of the
hypothyroidism. Of 27 patients who had isotope scans before treatment
was started, 11 (40%) were athyrotic, 10 (38%) had an ectopic gland,
and six (22%) probably had dyshormonogenesis. Treatment was started
with thyroxine at 100 µg/m2/24 hours at a mean age of 26 days (range 14-45). Serum TSH concentrations remained increased in 26 (81%) at 3 months, 20 (62.5%) at 6 months, and nine (28%) at 1 year
and beyond. The mean age for serum TSH to reach the normal range was
0.79 years (range 0.15-2.1 years). Diagnosis (in 27 patients) and
initial results (in 32) made no difference to the rate of fall.
© 1997 by Archives of Disease in Childhood
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This article has been cited by other articles:
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Hindmarsh, P C
(2002). Optimisation of thyroxine dose in congenital hypothyroidism. Arch. Dis. Child.
86: 73-75
[Full Text] -
SWIFT, P. G F, THOMAS, N., DATTA, V., CUTTS, C.
(1998). Factors involved in the rate of fall of thyroid stimulating hormone in treated hypothyroidism. Arch. Dis. Child.
79: 198f-198
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