Antibody persistence and Haemophilus influenzae type b carriage after infant immunisation with PRP-T
Oxford Vaccine Group,
Department of Paediatrics, John Radcliffe Hospital,
Oxford OX3 9DU
Correspondence to: Dr Heath.
Accepted 31 July 1997
OB JECTIVES
To assess the persistence of serum
Haemophilus influenzae type b antibodies and the
prevalence of H influenzae type b carriage in a group of
preschool age children previously vaccinated in infancy.
DESIGNNames were randomly selected from
immunisation records. Families were visited on five occasions over a
period of 12 months and throat swabs were taken from all family members
present, with blood obtained from children at the first and last visits.
RESULTSOne hundred and fifty three children at a
median age of 3.6 years had a geometric mean titre (GMT) of 1.06 µg/ml (95% CI 0.80 to 1.38). Eight per cent had an undetectable
antibody concentration, received a booster dose of plain PRP vaccine,
and responded with concentrations > 2 µg/ml. GMT at 4.5 years of
age was 0.89 µg/ml (0.69 to 1.16). Twelve children who had been
exposed to H influenzae had a GMT of 4.7 v
0.8 µg/ml for those without exposure.
CONCLUSIONSAccelerated immunisation against
H influenzae without a second year booster results in
persistence of satisfactory serum concentrations of antibody to 4.5 years of age. In those with undetectable antibody, immunological memory
may still be present.
© 1997 by Archives of Disease in Childhood
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