Article
Early infection and subsequent insulin dependent diabetes
a Metabolic Programming Group,
MRC Environmental Epidemiology Unit, University of Southampton, b Department of Child Health, Southampton General
Hospital
Correspondence to: Dr D I W Phillips, MRC Environmental Epidemiology Unit (University of Southampton), Southampton General Hospital, Tremona Road, Southampton SO16 6YD.
In a study of 58 children under the age of 16 with insulin
dependent diabetes (IDDM) and 172 matched non-diabetic controls, infection during the first year of life was associated with a reduction
in diabetes risk (odds ratio 0.81, 95% confidence interval 0.67 to
0.98, per infective episode). Decreased exposure to common infections
during infancy may be linked with subsequent IDDM.
© 1997 by Archives of Disease in Childhood
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