Increased plasma malondialdehyde associated with cerebellar structural defects
a Department of Paediatrics, University
Hospital Aachen, Germany, b Department of Paediatrics and Clinical Biochemistry,
University Hospital Amsterdam, The Netherlands
Correspondence to: Dr V Th Ramaekers, Department of Paediatrics, Medizinische Einrichtungen der RWTH, Pauwelsstrasse 30, D-52057 Aachen, Germany. Accepted 23 April 1997
BACKGROUND
Malondialdehyde (MDA) in plasma is
regarded as an indicator for increased lipid peroxidation.
METHODMeasurements of MDA concentrations in
plasma were compared among healthy children (n=31), patients with
neurological disorders or epileptic syndromes (n=15), and children with
pontocerebellar structural defects (n=31), where the cause or
genetic defect remained unknown.
RESULTSIn healthy children the median MDA value
was 5.86 nmol/ml (mean (SD) value: 6.25 (1.97), range: 3.76-11.19).
For the group with various neurological disorders or epilepsy, the
values were similar with the median value at 5.66 nmol/ml (range
0.22-10.86). Compared with healthy controls and the
neurological/epileptic group, the 31 children with pontocerebellar
structural defects had significantly increased MDA values with a median
value at 11.29 nmol/ml (mean (SD) value: 11.62 (3.27), range
3.65-19.22).
IMPLICATIONThese findings of increased plasma MDA
in the majority of children with pontocerebellar structural defects of
unknown origin raised the question whether increased lipid peroxidation
leads to prenatal and postnatal pontocerebellar maldevelopment or degeneration.
© 1997 by Archives of Disease in Childhood
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