Hepatitis GB virus-C/hepatitis G virus infection in liver disease
a Department of
Child Health, King's College School of Medicine and Dentistry and
Institute of Hepatology University College London Medical School,
London, b Institute of Hepatology University
College London Medical School, London, c King's College
Hospital, London: Department of Child Health, d Institute of Liver Studies, e Department of Child Health, King's College
School of Medicine and Dentistry, London
Correspondence to: and reprint requests to: Dr Alastair J Baker, Department of Child Health, King's College Hospital, Denmark Hill, London SE5 9RS.
Accepted 27 June 1997
Hepatitis GB virus-C (HGBV-C)/hepatitis G virus (HGV) infection
was investigated in 106 children with liver disease (54 boys and 52 girls, mean age 7.3 years); 12 with chronic hepatitis C virus
infection, 29 with positive hepatitis B surface antigen, nine with
idiopathic fulminant hepatic failure, seven with graft dysfunction
after liver transplantation associated with autoimmune features, 20 with cryptogenic liver disease, and 29 with autoimmune liver disease.
HGV RNA detected by reverse transcription polymerase chain reaction was
found to be positive in 4/106 patients (3.8%). Risk factors were
identified in three patients, including blood transfusion and/or
medical treatment in Eastern Europe. The prevalence was higher than
that of blood donors but lower than that of 2 adult patients with liver
disease. HGV is not associated with any specific disease group and does
not seem to be a major aetiological agent of liver disease in childhood
in the UK.
© 1997 by Archives of Disease in Childhood
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