Serum prolactin in coeliac disease: a marker for disease activity
a School of Nutritional Sciences, Hebrew
University of Jerusalem, Rehovot, b Division of
Medicine, Soroka Medical Center, Ben Gurion University, Beer Sheva, c Department
of Pediatrics, Carmel Medical Center, B Rappaport School of Medicine,
Technion
Israel Institute of Technology, Haifa, Israel
Correspondence to: Dr Ram Reifen, School of Nutritional Sciences, Hebrew University of Jerusalem, PO Box 12, Rehovot, Israel.
Accepted 21 April 1997
Prolactin, a polypeptide hormone of anterior pituitary origin,
has pronounced physiological effects on growth, reproduction, and
osmoregulation. Increasing evidence indicates that prolactin also has
an immunomodulatory influence on the immune system. The status of
prolactin in patients with coeliac disease was investigated by
obtaining serum samples from 48 patients with active and non-active coeliac disease. These were compared with samples from 20 children with
familial Mediterranean fever and 65 normal controls. Serum prolactin in
patients with active coeliac disease was significantly higher than in
the other groups studied and reference values. Serum prolactin
correlated well with the degree of mucosal atrophy and with the serum
concentration of antiendomysial antibodies. Prolactin may play a part
in immune modulation in the intestinal damage of coeliac disease and
serve as a potential marker for disease activity.
© 1997 by Archives of Disease in Childhood
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