Chronic bullous disease of childhood and a paecilomyces lung infection in chronic granulomatous disease
a University of Amsterdam, Netherlands:
Department of Dermatology, b Emma Children's Hospital, c Central Laboratory
of the Netherlands Red Cross Blood Transfusion Centre
Correspondence to: Dr Sillevis Smitt, Department of Dermatology, AO-228, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, Netherlands.
Accepted 24 April 1997
A 12 year old boy suffering from p67-phox
deficient chronic granulomatous disease presented with a bullous skin
disease and a lung infection with paecilomyces species. The
histopathology of a bullous lesion showed subepidermal blister
formation and microabcesses containing eosinophils in the dermal
papillae. By direct immunofluorescence, linear staining of IgA at the
dermal-epidermal junction was detected which confirmed the clinical
diagnosis of chronic bullous disease of childhood (linear IgA dermatosis)
© 1997 by Archives of Disease in Childhood
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