Cytokines in haemolytic uraemic syndrome associated with verocytotoxin-producing Escherichia coli infection
a Department of Nephrology, Birmingham Children's
Hospital, Ladywood Middleway, Birmingham B16 8ET, b Renal Research
Laboratory, University Hospital, Birmingham
Correspondence to: Dr Taylor.
Accepted 6 May 1997
The proinflammatory cytokines tumour necrosis factor-
(TNF-), interleukin (IL)-1
, IL-6, and IL-8 were measured in
plasma and urine samples from 19 children with verocytotoxin-producing Escherichia coli (VTEC) induced haemolytic
uraemic syndrome (HUS) and 30 controls. TNF- was detected in the
plasma of two cases and one control; IL-6 in the plasma of one, and the
urine of two cases, and in the plasma of one control. IL-1 and IL-8
were each identified in eight of the 19 cases and in one and two
controls respectively. Urinary IL-8 was found in seven cases, four of
whom had plasma concentrations below the limit of detection suggesting renal secretion of this cytokine. Cytokine concentrations did not
correlate with peripheral blood neutrophil count at onset of disease.
These data confirm the systemic release of cytokines responsible for
the coordination of acute inflammatory processes in some children with
VTEC induced HUS.
© 1997 by Archives of Disease in Childhood
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