One week treatment for Helicobacter pylori infection
Department of Paediatrics, University College
Dublin; Children's Research Centre, Our Lady's Hospital for Sick
Children, Dublin, Ireland
Correspondence to: Professor B Drumm, Professorial Unit, Children's Research Centre, Our Lady's Hospital for Sick Children, Crumlin, Dublin 12, Ireland.
Accepted 8 November 1996
Helicobacter pylori is associated with primary
antral gastritis, duodenal ulceration, and gastric cancer. Current
regimens for treating infection in children using bismuth and
antibiotics for two to six weeks are cumbersome. The aim of this study
was to evaluate a one week course of treatment. All children undergoing endoscopy were assessed for the presence of H pylori by
culture, histology, rapid urease test, and 13C urea breath
test. Infected children received a one week course of colloidal bismuth
subcitrate 480 mg/1.73 m2/day (maximum 120 mg four times a
day), combined with metronidazole 20 mg/kg/day (maximum 200 mg three
times a day), and clarithromycin 15 mg/kg/day (maximum 250 mg twice a
day). To optimise compliance, drugs were dispensed in a `Redidose'
box containing a compartment for each day, and subcompartments marked
`breakfast', `lunch', `dinner', and `bedtime'. Compliance and
side effects were assessed immediately after treatment. A urea breath
test was performed at least one month after treatment. Twenty two
children infected with H pylori were entered into the
study; 20 of these took all doses; two children suffered significant
side effects (diarrhoea and vomiting). H pylori was
eradicated in 21 of the 22 children (95.45%; 95% confidence interval
77% to 100%). This study shows that H pylori infection
in children can be cleared by a one week course of treatment.
© 1997 by Archives of Disease in Childhood
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
-
Behrens, R., Lang, T., Keller, K. M, Bindl, L., Becker, M., Rodeck, B., Küster, P., Wündisch, G. F, Stolte, M.
(1999). Dual versus triple therapy of Helicobacter pylori infection: results of a multicentre trial. Arch. Dis. Child.
81: 68-70
[Abstract] [Full Text] -
Goggin, N, Rowland, M, Imrie, C, Walsh, D, Clyne, M, Drumm, B
(1998). Effect of Helicobacter pylori eradication on the natural history of duodenal ulcer disease. Arch. Dis. Child.
79: 502-505
[Abstract] [Full Text] -
WALSH, D, DRUMM, B
(1997). Legislation and drug trials. Arch. Dis. Child.
76: 296-297
[Full Text]
- Full Text
- Full Text (PDF)
- Submit a response
- Alert me when this article is cited
- Alert me when eLetters are posted
- Alert me if a correction is posted
- Citation Map
Services
- Email this link to a friend
- Similar articles in ADC Online
- Similar articles in PubMed
- Add article to my folders
- Download to citation manager
- Request Permissions
Citing Articles
Google Scholar
PubMed
Topic Collections
Bookmark with
Register for free content
The full back archive is now available for all BMJ Journals. Institutional subscribers may access the entire archive as part of their subscription. Personal subscribers will also have access to all content when logged in. Non-subscribers who register have free access to all articles published before 2006 right back to volume 1 issue 1. Register here to access the free archive of all BMJ Journals.
Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.
