Respiratory morbidity from lymphocytic interstitial pneumonitis (LIP) in vertically acquired HIV infection
a Paediatric
Infectious Disease Unit, St George's Hospital, London, b Department of Epidemiology and Biostatistics,
Institute of Child Health, London
Correspondence to: Dr Mike Sharland, Paediatric Infectious Disease Unit, 5th Floor, Lanesborough Wing, St George's Hospital, London SW17 0QT.
Accepted 31
December 1996
The aim of the study was to define the respiratory morbidity
caused by lymphocytic interstitial pneumonitis (LIP) in children with
vertically acquired HIV infection. A retrospective case note review was
performed on 95 children attending three London hospitals. Clinical and
radiological evidence of LIP, acute lower respiratory tract infections,
and chronic lung disease was obtained using a structured protocol. A
diagnosis of LIP had been made in 33%, and an acute admission due to
acute lower respiratory tract infection had occurred in 42% of all
children (despite 99% taking regular co-trimoxazole prophylaxis).
Admission rates because of acute lower respiratory tract infection were
significantly higher in the LIP group (0.38 admissions/child year) than
in the non-LIP group (0.17 admissions/child year) (p = 0.0002).
Encapsulated bacteria (Streptococcus pneumoniae,
Haemophilus influenzae) were most frequently isolated.
Improved methods of prevention of acute lower respiratory tract
infection may help to reduce the severe respiratory morbidity seen in
children with LIP and HIV infection.
© 1997 by Archives of Disease in Childhood
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