ADC

HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS REGISTER
[Advanced]

This Article
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this link to a friend
Right arrow Similar articles in ADC Online
Right arrow Similar articles in PubMed
Right arrow Add article to my folders
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Koller, D.
Right arrow Articles by Eichler, I
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Koller, D.
Right arrow Articles by Eichler, I

Archives of Disease in Childhood, Vol 75, 498-501, Copyright © 1996 by Archives of Disease in Childhood.


PAPERS

Relationship between disease severity and inflammatory markers in cystic fibrosis

DY Koller, M Gotz, C Wojnarowski and I Eichler
Division of Allergy and Pulmonology, University Children's Hospital, Vienna, Austria.

To evaluate the clinical use of measuring neutrophil, lymphocyte, and eosinophil activities, serum myeloperoxidase (MPO), soluble interleukin- 2 receptors (sIL-2R), and eosinophil cationic protein (ECP) were measured in 98 patients with cystic fibrosis and in 85 healthy children. Serum concentrations of MPO, sIL-2R, and ECP were increased in patients with cystic fibrosis (median 807 micrograms/l, 4452 pg/ml, 48.8 micrograms/l, respectively) compared with the controls (median 319 micrograms/l, 2743 pg/ml, 9.4 micrograms/l). ECP concentrations, but not serum MPO or sIL-2R, were significantly related to disease severity assessed by the Shwachman-Kulczycki score and by pulmonary function (forced expiratory volume in one second % predicted). Neither ECP nor sIL-2R was influenced by Pseudomonas aeruginosa infection, acute pulmonary exacerbation, or atopy. Serum MPO, however, was strongly correlated with acute pulmonary exacerbation. In the light of these findings the measurement of serum ECP might thus be used for clinical monitoring and for assessing disease severity in cystic fibrosis. The measurement of serum MPO and sIL-2R did not correlate with the disease severity.


This article has been cited by other articles:


Home page
Am. J. Respir. Crit. Care Med.Home page
A. J. Sloane, R. A. Lindner, S. S. Prasad, L. T. Sebastian, S. K. Pedersen, M. Robinson, P. T. Bye, D. W. Nielson, and J. L. Harry
Proteomic Analysis of Sputum from Adults and Children with Cystic Fibrosis and from Control Subjects
Am. J. Respir. Crit. Care Med., December 1, 2005; 172(11): 1416 - 1426.
[Abstract] [Full Text] [PDF]


Home page
ThoraxHome page
D Foell, S Seeliger, T Vogl, H-G Koch, H Maschek, E Harms, C Sorg, and J Roth
Expression of S100A12 (EN-RAGE) in cystic fibrosis
Thorax, July 1, 2003; 58(7): 613 - 617.
[Abstract] [Full Text] [PDF]


Home page
Br Med BullHome page
C A. Hart and C. Winstanley
Persistent and aggressive bacteria in the lungs of cystic fibrosis children
Br. Med. Bull., March 1, 2002; 61(1): 81 - 96.
[Abstract] [Full Text] [PDF]


Home page
Arch. Dis. Child.Home page
R. L Smyth, N. M Croft, U. O'Hea, T. G Marshall, and A. Ferguson
Intestinal inflammation in cystic fibrosis
Arch. Dis. Child., May 1, 2000; 82(5): 394 - 399.
[Abstract] [Full Text]




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS REGISTER
ARCH DIS CHILD FETAL NEONATAL ED ED PRACTICE
Terms and conditions relating to subscriptions purchased online  ¦  Website terms and conditions  ¦  Privacy policy
Copyright © 1996 BMJ Publishing Group Ltd & Royal College of Paediatrics and Child Health