Calprotectin as a marker of inflammation in cystic fibrosis.

B E Golden, P A Clohessy, G Russell, M K Fagerhol

Department of Child Health, University of Aberdeen.

Calprotectin is an abundant neutrophil cytosolic protein released during neutrophil activation or death. The use of plasma calprotectin concentration as a marker of pulmonary inflammation was tested in 31 children with cystic fibrosis, none of whom was acutely unwell or pyrexic. Twenty three were receiving antibiotics, 21 had positive sputum cultures, but none of the traditional tests clearly diagnosed ongoing infection. Plasma calprotectin was significantly higher in the cystic fibrosis group than in matched controls. Sixteen children with cystic fibrosis had values above the control range (320-1570 micrograms/l). Their chest radiograph Northern score, an index of accumulated pulmonary involvement, and their plasma copper, an index of acute phase response, both correlated with plasma calprotectin. Plasma gamma-glutamyltransferase also correlated weakly with plasma calprotectin: thus, hepatic pathology may be a confounding variable. However, the data still suggested that plasma calprotectin is a better index of inflammation than the traditional indices in general use.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

• Oslejskova, L, Grigorian, M, Gay, S, Neidhart, M, Senolt, L (2008). The metastasis associated protein S100A4: a potential novel link to inflammation and consequent aggressive behaviour of rheumatoid arthritis synovial fibroblasts. Ann Rheum Dis 67: 1499-1504 [Abstract] [Full Text]  
• Foell, D., Kane, D., Bresnihan, B., Vogl, T., Nacken, W., Sorg, C., FitzGerald, O., Roth, J. (2003). Expression of the pro-inflammatory protein S100A12 (EN-RAGE) in rheumatoid and psoriatic arthritis. Rheumatology (Oxford) 42: 1383-1389 [Abstract] [Full Text]  
• Ahmad, A., Bayley, D. L., He, S., Stockley, R. A. (2003). Myeloid Related Protein-8/14 Stimulates Interleukin-8 Production in Airway Epithelial Cells. Am. J. Respir. Cell Mol. Bio. 29: 523-530 [Abstract] [Full Text]  
• Foell, D, Seeliger, S, Vogl, T, Koch, H-G, Maschek, H, Harms, E, Sorg, C, Roth, J (2003). Expression of S100A12 (EN-RAGE) in cystic fibrosis. Thorax 58: 613-617 [Abstract] [Full Text]  
• Nisapakultorn, K., Ross, K. F., Herzberg, M. C. (2001). Calprotectin Expression Inhibits Bacterial Binding to Mucosal Epithelial Cells. Infect. Immun. 69: 3692-3696 [Abstract] [Full Text]  
• Harrison, C. A., Raftery, M. J., Walsh, J., Alewood, P., Iismaa, S. E., Thliveris, S., Geczy, C. L. (1999). Oxidation Regulates the Inflammatory Properties of the Murine S100 Protein S100A8. J. Biol. Chem. 274: 8561-8569 [Abstract] [Full Text]  
• Pillay, S. N., Asplin, J. R., Coe, F. L. (1998). Evidence that calgranulin is produced by kidney cells and is an inhibitor of calcium oxalate crystallization. Am. J. Physiol. Renal Physiol. 275: F255-F261 [Abstract] [Full Text]