Outcome among surviving very low birthweight infants: a meta-analysis.

G J Escobar, B Littenberg, D B Petitti

Department of Pediatrics, Kaiser Permanente Medical Center, Walnut Creek, California 94596-5300.

Because published outcome studies are the only available source of data about the morbidity among surviving very low birthweight infants (VLBW, less than 1500 g) a search was carried out of 1136 references in the English language. A total of 111 outcome studies were found that reported morbidity data in cohorts of VLBW infants born since 1960. The methods used and results obtained in these studies were systematically assessed. No agreement exists about the definition of study populations, descriptive statistics, or measurement of outcome. Follow up ranged from six months to 14 years. In 85 cohorts the incidence of cerebral palsy was recorded, and in 106 that of disability. Studies that followed up infants for longer time periods reported higher incidences of disability. Studies from the United States reported higher incidences of disability than those from other countries. The median incidence of cerebral palsy among all the cohorts studied was 7.7%, and the median incidence of disability was 25.0%. Despite substantial improvements in the mortality of VLBW infants, poor outcomes among survivors are common.

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• Kirby, R. S. (1999). A Parable Wrapped in an Enigma: Population-Based Assessments of Outcomes Among High-Risk Neonates Are Even Less Achievable in the Age of Clinical Informatics. Arch Pediatr Adolesc Med 153: 789-792 [Full Text]  
• Hadders-Algra, M., Brogren, E., Katz-Salamon, M., Forssberg, H. (1999). Periventricular leucomalacia and preterm birth have different detrimental effects on postural adjustments. Brain 122: 727-740 [Abstract] [Full Text]  
• Singer, L. T., Salvator, A., Guo, S., Collin, M., Lilien, L., Baley, J. (1999). Maternal Psychological Distress and Parenting Stress After the Birth of a Very Low-Birth-Weight Infant. JAMA 281: 799-805 [Abstract] [Full Text]  
• Spitzer, A. R. (1998). Follow-up of the Low-Birth-Weight Infant: Where Do We Go From Here?. CLIN PEDIATR 37: 547-549  
• Tin, W., Fritz, S., Wariyar, U., Hey, E. (1998). Outcome of very preterm birth: children reviewed with ease at 2 years differ from those followed up with difficulty. Arch. Dis. Child. Fetal Neonatal Ed. 79: 83F-87 [Abstract] [Full Text]  
• Resnick, M. B., Gomatam, S. V., Carter, R. L., Ariet, M., Roth, J., Kilgore, K. L., Bucciarelli, R. L., Mahan, C. S., Curran, J. S., Eitzman, D. V. (1998). Educational Disabilities of Neonatal Intensive Care Graduates. Pediatrics 102: 308-314 [Abstract] [Full Text]  
• Wolke, D (1998). Psychological development of prematurely born children. Arch. Dis. Child. 78: 567-570 [Full Text]  
• Lorenz, J. M., Wooliever, D. E., Jetton, J. R., Paneth, N. (1998). A Quantitative Review of Mortality and Developmental Disability in Extremely Premature Newborns. Arch Pediatr Adolesc Med 152: 425-435 [Abstract] [Full Text]  
• Fowlie, P W, Tarnow-Mordi, W O, Gould, C R, Strang, D (1998). Predicting outcome in very low birthweight infants using an objective measure of illness severity and cranial ultrasound scanning. Arch. Dis. Child. Fetal Neonatal Ed. 78: 175F-178 [Abstract] [Full Text]  
• Farel, A. M., Hooper, S. R., Teplin, S. W., Henry, M. M., Kraybill, E. N. (1998). Very-Low-Birthweight Infants at Seven Years: An Assessment of the Health and Neurodevelopmental Risk Conveyed by Chronic Lung Disease. J Learn Disabil 31: 118-126 [Abstract]  
• Schaap, A H P, Wolf, H, Bruinse, H W, den Ouden, A L, Haas, H S.-d., van Ertbruggen, I, Treffers, P E (1997). Influence of obstetric management on outcome of extremely preterm growth retarded infants. Arch. Dis. Child. Fetal Neonatal Ed. 77: 95F-99 [Abstract] [Full Text]  
• McCormick, M. C. (1997). The Outcomes of Very Low Birth Weight Infants: Are We Asking the Right Questions?. Pediatrics 99: 869-869 [Full Text]  
• Cooper, P. A., Sandler, D. L. (1997). Outcome of Very Low Birth Weight Infants at 12 to 18 Months of Age in Soweto, South Africa. Pediatrics 99: 537-544 [Abstract] [Full Text]  
• McCarton, C. M., Brooks-Gunn, J., Wallace, I. F., Bauer, C. R., Bennett, F. C., Bernbaum, J. C., Broyles, R. S., Casey, P. H., McCormick, M. C., Scott, D. T., Tyson, J., Tonasela, J., Meinen, C. L. (1997). Results at Age 8 Years of Early Intervention for Low-Birth-Weight Premature Infants: The Infant Health and Development Program. JAMA 277: 126-132 [Abstract]  
• Johnson, A. (1997). Follow up studies: a case for a standard minimum data set. Arch. Dis. Child. Fetal Neonatal Ed. 76: 61F-63 [Full Text]  
• Halsey, C. L., Collin, M. F., Anderson, C. L. (1996). Extremely Low-Birth-Weight Children and Their Peers: A Comparison of School-Age Outcomes. Arch Pediatr Adolesc Med 150: 790-794 [Abstract]  
• McCormick, M. C. (1994). Survival of Very Tiny Babies -- Good News and Bad News. NEJM 331: 802-803 [Full Text]  
• Kuban, K.C.K., Leviton, A. (1994). Cerebral Palsy. NEJM 330: 188-195 [Full Text]  
• McCormick, M. C., Brooks-Gunn, J., Workman-Daniels, K., Turner, J., Peckham, G. J. (1992). The Health and Developmental Status of Very Low--Birth-Weight Children at School Age. JAMA 267: 2204-2208 [Abstract]