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Archives of Disease in Childhood 1990;65:930-935; doi:10.1136/adc.65.9.930
Copyright © 1990 BMJ Publishing Group Ltd & Royal College of Paediatrics and Child Health.

Slow release carbamazepine in treatment of poorly controlled seizures.

S W Ryan, I Forsythe, R Hartley, M Haworth, C J Bowmer

Department of Paediatrics and Child Health, General Infirmary, Belmont Grove, Leeds.

Thirty three children with poorly controlled epilepsy, and six new patients, were treated with slow release carbamazepine. Twelve of the former had a reduction in the number of seizures of more than half, and 10 had fewer side effects. Three of the new patients stopped having seizures. Variations in plasma concentrations between doses was significantly less when patients took the slow release preparation (22%) compared with the standard preparation (41%). Slow release carbamazepine may improve the conditions of children whose seizures are poorly controlled.


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